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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.
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Archived Hot Topics of the Day By Date
Integration of pathologic characteristics, genetic risk and lifestyle exposure for colorectal cancer survival assessment
J Xin et al, Nature Comm, April 8, 2024
(Posted: Apr 09, 2024 8AM)
What to Know About Lynch Syndrome
ThedaCare Genetic Counseling, March 2024
(Posted: Apr 01, 2024 9AM)
Lynch Syndrome Ups Risk for Colorectal, Other Cancers
E Herlache, Cancer Care, March 2024
(Posted: Mar 23, 2024 6AM)
Cell-free DNA for Colorectal Cancer Screening.
Y M Dennis Lo et al. N Engl J Med 2024 3 (11) 1047-1050
(Posted: Mar 14, 2024 10AM)
Next-Generation Multitarget Stool DNA Test for Colorectal Cancer Screening.
Thomas F Imperiale et al. N Engl J Med 2024 3 (11) 984-993
(Posted: Mar 14, 2024 10AM)
Improving Noninvasive Colorectal Cancer Screening.
John M Carethers et al. N Engl J Med 2024 3 (11) 1045-1046
(Posted: Mar 14, 2024 10AM)
A Cell-free DNA Blood-Based Test for Colorectal Cancer Screening.
Daniel C Chung et al. N Engl J Med 2024 3 (11) 973-983
(Posted: Mar 14, 2024 10AM)
Identification of people with Lynch syndrome from those presenting with colorectal cancer in England: baseline analysis of the diagnostic pathway
FE McRonald et al, EJHG, February 15, 2024
(Posted: Feb 15, 2024 9AM)
Maximizing scarce colonoscopy resources: the crucial role of Stool-Based tests.
Gloria D Coronado et al. J Natl Cancer Inst 2024 2
(Posted: Feb 04, 2024 4PM)
Remembering My Brother Who Died of Cancer January 11, 2024 Georgia Hurst Blog Article
G Hurst, Cure, January 11, 2024
(Posted: Jan 14, 2024 10AM)
Influence of family history on penetrance of hereditary cancers in a population setting.
Leigh Jackson et al. EClinicalMedicine 2023 11 102159
(Posted: Nov 14, 2023 8AM)
Personalized Initial Screening Age for Colorectal Cancer in Individuals at Average Risk.
Xuechen Chen et al. JAMA Netw Open 2023 10 (10) e2339670
(Posted: Oct 27, 2023 9AM)
Multitarget Stool RNA Test for Colorectal Cancer Screening.
Erica K Barnell et al. JAMA 2023 10
(Posted: Oct 24, 2023 2PM)
Molecular disparities in colorectal cancers of White Americans, Alabama African Americans, and Oklahoma American Indians.
Hiroshi Y Yamada et al. NPJ Precis Oncol 2023 8 (1) 79
(Posted: Aug 21, 2023 8AM)
How the Y chromosome makes some cancers more deadly for men
H Ledford, Nature, June 21, 2023
(Posted: Jun 22, 2023 7AM)
Bayesian risk prediction model for colorectal cancer mortality through integration of clinicopathologic and genomic data.
Melissa Zhao et al. NPJ Precis Oncol 2023 6 (1) 57
(Posted: Jun 11, 2023 8AM)
The "Scope" of Colorectal Cancer Screening in Lynch Syndrome: Is There an Optimal Interval?
Leah H Biller et al. J Natl Cancer Inst 2023 5
(Posted: May 05, 2023 9AM)
Exploring the complex relationship between gut microbiota and risk of colorectal neoplasia using bidirectional Mendelian Randomization analysis.
Wanxin Li et al. Cancer Epidemiol Biomarkers Prev 2023 4
(Posted: Apr 29, 2023 3PM)
Early Detection of Molecular Residual Disease and Risk Stratification for Stage I to III Colorectal Cancer via Circulating Tumor DNA Methylation.
Shaobo Mo et al. JAMA Oncol
(Posted: Apr 21, 2023 6AM)
Liquid Biopsy Assessment of Molecular Residual Disease in Localized Colorectal Cancer: Is It Ready for Prime Time?
Juan Ruiz-Bañobre et al. JAMA Oncol
(Posted: Apr 21, 2023 6AM)
Evaluating Colonoscopy Screening Intervals in Patients with Lynch Syndrome from a Large Canadian Registry
M Aronson et al, JNCI, March 25, 2023
(Posted: Mar 25, 2023 8AM)
A common cancer at an uncommon age.
Marios Giannakis et al. Science (New York, N.Y.) 2023 3 (6637) 1088-1090
(Posted: Mar 21, 2023 8AM)
Immunotherapy Success for Microsatellite Stable Colorectal Cancers-Searching for the Horizon.
Emil Lou et al. JAMA oncology 2023 3
(Posted: Mar 09, 2023 8PM)
Regorafenib, Ipilimumab, and Nivolumab for Patients With Microsatellite Stable Colorectal Cancer and Disease Progression With Prior Chemotherapy: A Phase 1 Nonrandomized Clinical Trial.
Marwan Fakih et al. JAMA oncology 2023 3
(Posted: Mar 09, 2023 8PM)
Identification of specific susceptibility loci for the early-onset colorectal cancer.
Haoxue Wang et al. Genome medicine 2023 3 (1) 13
(Posted: Mar 04, 2023 8AM)
Codon-specific KRAS mutations predict survival benefit of trifluridine/tipiracil in metastatic colorectal cancer.
Joris van de Haar et al. Nature medicine 2023 3
(Posted: Mar 03, 2023 8AM)
Risk assessment for colorectal cancer via polygenic risk score and lifestyle exposure: a large-scale association study of East Asian and European populations.
Junyi Xin et al. Genome medicine 2023 1 (1) 4
(Posted: Jan 25, 2023 8AM)
Comparative Effectiveness of Immune Checkpoint Inhibitors vs Chemotherapy in Patients With Metastatic Colorectal Cancer With Measures of Microsatellite Instability, Mismatch Repair, or Tumor Mutational Burden.
Quintanilha Julia C F et al. JAMA network open 2023 1 (1) e2252244
(Posted: Jan 24, 2023 8AM)
Molecular residual disease and efficacy of adjuvant chemotherapy in patients with colorectal cancer.
Kotani Daisuke et al. Nature medicine 2023 1
(Posted: Jan 17, 2023 9AM)
Improved two-step testing of genome-wide gene–environment interactions
ES Kawagushi et al, Genetic Epidemiology, December 26, 2022
(Posted: Dec 26, 2022 11AM)
Assessment of Body Mass Index, Polygenic Risk Score, and Development of Colorectal Cancer.
Chen Xuechen et al. JAMA network open 2022 12 (12) e2248447
(Posted: Dec 23, 2022 6PM)
Adagrasib with or without Cetuximab in Colorectal Cancer with Mutated KRAS G12C
R Yaeger et al, NEJM, December 21, 2022
(Posted: Dec 22, 2022 8AM)
Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries.
Fernandez-Rozadilla Ceres et al. Nature genetics 2022 12
(Posted: Dec 21, 2022 1PM)
Integrating genome-wide polygenic risk scores and non-genetic risk to predict colorectal cancer diagnosis using UK Biobank data: population based cohort study
SEW Briggs et al, BMJ, November 2022
(Posted: Nov 14, 2022 7AM)
Comparison of Germline Genetic Testing Before and After a Medical Policy Covering Universal Testing Among Patients With Colorectal Cancer
C Moretz et al, JAMA Network Open, October 24, 2022
(Posted: Oct 24, 2022 0PM)
An updated counseling framework for moderate-penetrance colorectal cancer susceptibility genes
KE Breen et al, Genetics in Medicine, October 12, 2022
(Posted: Oct 12, 2022 9AM)
DNA Methylation Profile in CpG-depleted Regions Uncovers a High-Risk Subtype of Early-stage Colorectal Cancer.
Yu Huichuan et al. Journal of the National Cancer Institute 2022 9
(Posted: Oct 02, 2022 8AM)
A Methylation-Based Prognostic Signature in Stage II Colorectal Patients: Considerations for Clinical Adoption.
Romesser Paul B et al. Journal of the National Cancer Institute 2022 9
(Posted: Oct 02, 2022 8AM)
A biomarker of response to therapy in metastatic BRAFV600E colorectal cancers
Nature Research Briefing, September 14, 2022
(Posted: Sep 15, 2022 6AM)
Genetic Testing Challenges in Oncology: Lynch Syndrome Diagnosis Despite Negative Test Results
T Ray, Precision Oncology News, August 29, 2022
(Posted: Aug 30, 2022 9AM)
Bowel cancer: what role do our genes play?
Genetics Education Program, August 19, 2022
(Posted: Aug 21, 2022 3PM)
Genomic and transcriptomic determinants of response to neoadjuvant therapy in rectal cancer.
Chatila Walid K et al. Nature medicine 2022 8
(Posted: Aug 16, 2022 10AM)
Circulating tumor DNA to guide rechallenge with panitumumab in metastatic colorectal cancer: the phase 2 CHRONOS trial.
Sartore-Bianchi Andrea et al. Nature medicine 2022 8
(Posted: Aug 03, 2022 6AM)
Identification of two intrinsic epithelial subtypes of colorectal cancer.
et al. Nature genetics 2022 7
(Posted: Jul 10, 2022 2PM)
A novel AI device for real-time optical characterization of colorectal polyps
C Biffi et al, NPJ Digital Medicine, June 30, 2022
(Posted: Jun 30, 2022 7AM)
Comprehensive profiling of 1015 patients’ exomes reveals genomic-clinical associations in colorectal cancer
Q Zhao et al, Nature Comms, April 29, 2022
(Posted: Apr 29, 2022 0PM)
Lynch syndrome; towards more personalized management?
J Llach et al, Best Practice & Research Clinical Gastroenterology, March 2022
(Posted: Apr 20, 2022 9AM)
Opportunities for personalizing colorectal cancer care: an analysis of SEER-medicare data
ZT Rivers et al, The PGX journal March 31, 2022
(Posted: Apr 02, 2022 8AM)
Effect of Patient-Directed Messaging on Colorectal Cancer Screening
A Randomized Clinical Trial
A Oyalowo et al, JAMA Network Open, March 31, 2022
(Posted: Apr 01, 2022 1PM)
Evaluation of Comparative Surveillance Strategies of Circulating Tumor DNA, Imaging, and Carcinoembryonic Antigen Levels in Patients With Resected Colorectal Cancer
M Fakih et al, JAMA Network Open
(Posted: Mar 09, 2022 11AM)
Index case identification and outcomes of cascade testing in high-risk breast and colorectal cancer predisposition genes
M Abedalthagafi, EJHG, January 22, 2022
(Posted: Jan 24, 2022 2PM)
30 year experience of index case identification and outcomes of cascade testing in high-risk breast and colorectal cancer predisposition genes
ER Woodward et al, EJHG, December 6, 2021
(Posted: Dec 06, 2021 6AM)
Identifying Diagnostic MicroRNAs and Investigating Their Biological Implications in Rectal Cancer
JK Kim et al, JAMA Network Open, December 4, 2021
(Posted: Dec 05, 2021 3PM)
Circulating tumor DNA-guided treatment with pertuzumab plus trastuzumab for HER2-amplified metastatic colorectal cancer: a phase 2 trial
Y Nakamura et al, Nature Medicine, November 11, 2021
(Posted: Nov 11, 2021 0PM)
Racial and Ethnic Disparities Among Participants in Precision Oncology Clinical Studies
CM Aldriguetti et al, JAMA Network Open, November 8, 2021
(Posted: Nov 09, 2021 6AM)
KRAS and BRAF Mutations in Stage II/III Colon Cancer: A Systematic Review and Meta-Analysis.
Formica Vincenzo et al. Journal of the National Cancer Institute 2021 9
(Posted: Sep 22, 2021 9AM)
Importance of Family History of Colorectal Cancer In Situ Versus Invasive Colorectal Cancer: A Nationwide Cohort Study.
Tian Yu et al. Journal of the National Comprehensive Cancer Network : JNCCN 2021 1-6
(Posted: Sep 17, 2021 6AM)
Clinical Response to Immunotherapy Targeting Programmed Cell Death Receptor 1/Programmed Cell Death Ligand 1 in Patients With Treatment-Resistant Microsatellite Stable Colorectal Cancer With and Without Liver Metastases
C Wang et al, JAMA Network Open, August 9, 2021
(Posted: Aug 10, 2021 10AM)
Pattern of DNA Damage Links Colorectal Cancer and Diet High in Red Meat
NCI, June 2021
(Posted: Aug 02, 2021 4PM)
Vaccine to Prevent Hereditary Cancers Nears Human Trials
S Jenks, NCI Blog, July 2021
(Posted: Jul 18, 2021 7AM)
Prospective Statewide Study of Universal Screening for Hereditary Colorectal Cancer: The Ohio Colorectal Cancer Prevention Initiative.
Pearlman Rachel et al. JCO precision oncology 2021 7
(Posted: Jul 14, 2021 6AM)
Expanding Germline Testing to All Patients With Esophagogastric Cancers—Easy to Do, Harder to Justify
JAMA Network Open, July 12, 2021
(Posted: Jul 13, 2021 7AM)
MFHP Cancer
CDC, July 2021
(Posted: Jul 11, 2021 2PM)
Characteristics of Early-Onset vs Late-Onset Colorectal Cancer: A Review.
et al. JAMA surgery 2021 7
(Posted: Jul 01, 2021 7AM)
Genetic testing for inherited colorectal cancer and polyposis, 2021 revision: a technical standard of the American College of Medical Genetics and Genomics (ACMG)
R Mao et al, Genetics in Medicine, June 17, 2021
(Posted: Jun 18, 2021 6AM)
Variation in the risk of colorectal cancer in families with Lynch syndrome: a retrospective cohort study
The International Mismatch Repair Consortium, The Lancet Oncology, June 7, 2021
(Posted: Jun 09, 2021 7AM)
Clinical Value of Consensus Molecular Subtypes in Colorectal Cancer: A Systematic Review and Meta-Analysis
ST Hoorn et al, JNCI, June 2021
(Posted: Jun 07, 2021 8AM)
Identification of microbial markers across populations in early detection of colorectal cancer
Y Wu et al, Nat Comms, May 24, 2021
(Posted: May 25, 2021 7AM)
Risk of colorectal cancer in first degree relatives of patients with colorectal polyps: nationwide case-control study in Sweden
M Song et al, BMJ May 2021
(Posted: May 05, 2021 7AM)
Interpretable survival prediction for colorectal cancer using deep learning
E Wulczyn et al, NPJ Digital Medicine, April 19, 2021
(Posted: Apr 19, 2021 9AM)
Effectiveness of patient-targeted interventions to inform decision making and improve uptake of colorectal cancer genetic evaluation for at-risk individuals: A systematic review.
Li Huanhuan et al. International journal of nursing studies 2021 118103928
(Posted: Apr 16, 2021 10AM)
Stool-based Colorectal Cancer Screening in the COVID-19 Era
WD Dotson et al, CDC Blog, April, 12, 2021
(Posted: Apr 13, 2021 7AM)
A Proclamation on National Colorectal Cancer Awareness Month, 2021
The White House, March 1, 2021
(Posted: Mar 03, 2021 7AM)
High expression of ACE2 and TMPRSS2 and clinical characteristics of COVID-19 in colorectal cancer patients
C Liu et al, NPJ Genomic Medicine, January 21, 2021
(Posted: Jan 22, 2021 9AM)
Pandemic Spotlights In-home Colon Cancer Screening Tests
MC Jaclevic, JAMA, December 23, 2020
(Posted: Dec 24, 2020 7AM)
Pembrolizumab in Microsatellite-Instability–High Advanced Colorectal Cancer
T Andre et al, NEJM, December 2, 2020
(Posted: Dec 03, 2020 7AM)
Pembrolizumab in MSI-H–dMMR Advanced Colorectal Cancer — A New Standard of Care
A Grothey, NEJM, December 2, 2020
(Posted: Dec 03, 2020 7AM)
Rising incidence of early-onset colorectal cancer - a call to action.
Akimoto Naohiko et al. Nature reviews. Clinical oncology 2020 Nov
(Posted: Nov 24, 2020 8AM)
Association of mismatch repair status with survival and response to neoadjuvant chemo(radio)therapy in rectal cancer
SB Ye, NPJ Precision Oncology, September 8, 2020
(Posted: Sep 09, 2020 9AM)
Effect of a Digital Health Intervention on Decreasing Barriers and Increasing Facilitators for Colorectal Cancer Screening in Vulnerable Patients
NMD Thompson et al, CEBP, August 2020
(Posted: Sep 01, 2020 8AM)
Genetic Disease Risk Impacted by Entire Genome, Study Reveals
J Kent, Health Analytics, August 27, 2020
(Posted: Aug 28, 2020 8AM)
Genome-wide Modeling of Polygenic Risk Score in Colorectal Cancer Risk.
Thomas Minta et al. American journal of human genetics 2020 Jul
(Posted: Aug 09, 2020 0PM)
A Genomic Test for Colorectal Cancer Risk: Is This Acceptable and Feasible in Primary Care?
S Saya et al, Public Health Genomics, July 2020
(Posted: Jul 21, 2020 7AM)
ctDNA applications and integration in colorectal cancer: an NCI Colon and Rectal–Anal Task Forces whitepaper
A Dasari et al, Nature Rev Clin Oncol, July 6, 2020
(Posted: Jul 07, 2020 10AM)
Clinical, Pathology, Genetic, and Molecular Features of Colorectal Tumors in Adolescents and Adults 25 Years or Younger.
de Voer Richarda M et al. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2020 Jun
(Posted: Jun 28, 2020 3PM)
Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double-blind, randomised, placebo-controlled trial
J Burn et al, The Lancet June 13, 2020
(Posted: Jun 13, 2020 7AM)
Local cellular cues that influence the immunology of colorectal cancer treatment
GP Donaldson et al, Nature Medicine, May 25, 2020
(Posted: May 26, 2020 7AM)
Efficacy of Immunotherapy in Microsatellite-Stable or Mismatch Repair Proficient Colorectal Cancer—Fact or Fiction?
RB Corcoran et al, JAMA Oncology, May 7, 2020
(Posted: May 08, 2020 9AM)
NCCN Updates Clinical Practice Guideline for Colorectal Cancer
JCCN, May 1, 2020
(Posted: May 02, 2020 8AM)
Potential impact of family history–based screening guidelines on the detection of early‐onset colorectal cancer
S Gupta et al, Cancer, April 20, 2020
(Posted: Apr 20, 2020 7AM)
New study highlights importance of family history-based screening for colorectal cancer
H Zia, Stat News, April 20, 2020
(Posted: Apr 20, 2020 7AM)
Associations Between Mutations in MSH6 and PMS2 and Risk of Surveillance-detected Colorectal Cancer.
Lamba Mehul et al. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2020 Mar
(Posted: Apr 08, 2020 9AM)
Cost-effectiveness Evaluation of Targeted Surgical and Endoscopic Therapies for Early Colorectal Adenocarcinoma Based on Biomarker Profiles
SR Jang et al. JAMA Network Open, March 9, 2020
(Posted: Mar 10, 2020 8AM)
Assessment of Treatment Cost-effectiveness Using a Colorectal Cancer Mutation Profile
TJ Yeatman et al, JAMA Netwotk Open, March 9, 2020
(Posted: Mar 10, 2020 8AM)
What Is Colorectal Cancer Screening?
CDC, March 2020
(Posted: Mar 09, 2020 8AM)
Should polygenic risk scores be used in risk-stratified colorectal cancer screening?
WD Dotson et al, CDC Blog Post, February 24, 2020
(Posted: Feb 25, 2020 9AM)
Deep learning for prediction of colorectal cancer outcome: a discovery and validation study.
Skrede Ole-Johan et al. Lancet (London, England) 2020 Feb (10221) 350-360
(Posted: Feb 03, 2020 9AM)
Gut Microbiome Link to Increased CRC in Younger Adults?
R Nelson, Medscape, January 27, 2020
(Posted: Feb 02, 2020 9AM)
A new comprehensive colorectal cancer risk prediction model incorporating family history, personal characteristics, and environmental factors.
Zheng Yingye et al. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2020 Jan
(Posted: Jan 16, 2020 8AM)
Improving cancer screening programs
M Kalager et al, Science, January 10, 2020
(Posted: Jan 11, 2020 11AM)
Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
- Page last reviewed:Feb 1, 2024
- Page last updated:May 01, 2024
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